Product News and Recalls

Drug used for prevention of epileptic seizures can cause cardiac failure

October 30, 2008 – Propofol is an intravenous drug manufactured by AstraZeneca under the brand name Diprivan. It was originally designed for use as a general anesthetic during surgery or other procedures like intubation or ventilation. However, for years it has also been prescribed to prevent epileptic seizures in people who suffer from refractory status epilepticus (RSE). A recently completed study by the Mayo Clinic indicated that long-term use of the drug can cause propofol infusion syndrome, a condition marked by the presence of cardiac failure, cardiopulmonary arrest, or renal failure, all of which are potentially fatal. The condition follows a very aggressive course that is usually irreversible.