Invokana (SGLT2 Inhibitor) Lawsuits for Ketoacidosis, Bone Fractures, and Kidney Failure

The Lopez McHugh pharmaceutical attorneys are investigating Invokana ketoacidosis lawsuits, as well as other SGLT2 inhibitor lawsuits. If you or someone you know were diagnosed with diabetic ketoacidosis, kidney failure, severe infection (genital mycotic infections), or a fracture while taking Invokana, find out if you have a claim by submitting the form on the right-hand side, or calling us, at 877-703-7070.

Joshua Mankoff, Esquire is heading the Lopez McHugh team on this case, and has been appointed as a co-chair of the American Association of Justice SGLT2 litigation group, to take a leadership role in coordinating Invokana cases across the country.

What is an SGLT2 Inhibitor?

sglt2 inhibitors like invokana are being linked to diabetic ketoacidosisSGLT2 inhibitors are prescription medications that are supposed to help lower blood sugar in adults with type 2 diabetes. SGLT2 is short for sodium-glucose co-transporter-2. These medications are approved by the Food & Drug Administration to lower blood sugar by causing the kidneys to remove sugar from the body through the urine. The currently available SGLT2 inhibitors include:

  • Invokana (canagliflozin);
  • Invokamet (canagliflozin and metformin);
  • Jardiance (empagliflozin);
  • Xigduo XR (dapagliflozin and metformin);
  • Farxiga (dapagliflozin); and
  • Glyxambi (empagliflozin and linagliptin).

What’s wrong with these drugs?

According to FDA Adverse Event Reports, use of SGLT2 inhibitors for diabetes has been associated with patients developing diabetic ketoacidosis, or too much acid in the blood. The FDA issued a Drug Safety Communication warning diabetes patients using SGLT2 inhibitors to watch for signs of ketoacidosis such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. The warning was issued after 20 cases of ketoacidosis were identified in the FDA’s Database of Adverse Events related to the use of diabetes medications known as SGLT2 inhibitors such as Invokana and Invokamet.

An update to that communication indicates that severe infections might develop as a result of that ketoacidosis. Reports show that several patients taking SGLT2 inhibitors contracted urinary tract infections which then progressed to become life-threatening blood infections (urosepsis) as well as infections of the kidneys (pyelonephritis). At least one study suggests that genital mycotic infections resulting in the need for circumcision may be related to the use of Invokana.

In addition, we have spoken with experts who are concerned that Invokana may cause kidney failure. Because these drugs use the kidneys to lower blood sugar, they put extra stress on the kidneys, can increase the risk of kidney failure.

The FDA as also issued an alert about bone fractures and bone loss. Specifically patients taking 300mg of Invokana were nearly 50% more likely to suffer a fracture, with some fractures occurring as early as 12 weeks after the start of treatment. Hip bone density declined by as much as 1.2% over two years. A clinical trial also measured reduced femoral neck bone density.

What is diabetic ketoacidosis?

diabetic ketoacidosis occurs when ketones are released into the bloodstreamDiabetic ketoacidosis can be life threatening. The condition occurs when the body’s cells are unable to get the sugar they need for energy. Starved of those vital sugars, the body then begins to break down fat and muscle for energy instead and releases ketones into the blood.

The release of ketones into the blood results in too much acid in the blood: a chemical imbalance known as ketoacidosis. Diabetic ketoacidosis may require hospitalization for treatment and can result in diabetic coma, brain swelling, or death.

Should I contact a lawyer if I’ve taken an SGLT2 Inhibitor?

If you or a loved one developed diabetic ketoacidosis, severe infection, kidney failure, or a fracture while taking Invokana or another SGLT2 inhibitor, we believe that you should speak to a pharmaceutical lawyer about your legal options. You may be entitled to compensation for your injuries and losses through a SGLT2 inhibitor lawsuit. And although the FDA has made an announcement about diabetic ketoacidosis and bone fractures, we believe that many doctors and patients are not aware of the problems linked with these drugs. If you were injured, you can help us get the word out and prevent others from being harmed.

The Lopez McHugh team is experienced in investigating and pursuing pharmaceutical lawsuits and can help you determine if a ketoacidosis lawsuit or other SGLT2 inhibitor lawsuit is for you. Contact our SGLT2 inhibitor lawyers today for a free consultation.