Product News and Recalls

Topamax and Birth Defects

Several studies show that Topamax, or topiramate, can cause or increase the risk of birth defects.

Topamax is an anti-seizure drug manufactured by Johnson & Johnson.  It is also prescribed to treat migraines and bi-polar disorder. Hundreds of lawsuits have been filed across the United States, claiming that Topamax caused cleft lip, cleft palate, or other birth defects.

Although cleft lip and cleft palate can occur in the normal population, several studies demonstrate that Topamax causes an increased risk of these birth defects. One study, based on the North American Antiepileptic Drug Pregnancy Registry, found the risk was 21 times as much for babies whose mothers used Topamax.  The risk from Topamax was also found to be 5 to 7 times higher than that from other anti-seizure drugs.

The UK Epilepsy and Pregnancy Register reported a similar increase in risk, 16 times as much. A third, smaller study demonstrated an 11-fold increase in risk over other anti-seizure drugs.

If you or a loved one used Topamax or topiramate during pregnancy and gave birth to a child with cleft lip, cleft palate or other birth defects, contact Lopez McHugh, LLP for a free legal consultation. You can reach us by calling toll-free at 1-877-703-7070.